HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: H2B2C (Q6DN03)
Putative histone H2B type 2-C (H2B-clustered histone 20 pseudogene) (Histone H2B.t) (H2B/t)
Gene: H2BC20P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30021884
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 193
+	Hs
		1150515 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		H2B2C_HUMAN (1-193): 7.74e-106: 303: 100.00
+	Hs
		420800 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1J_HUMAN (1-94): 1.78e-40: 135: 93.62
+	Hs
		241436 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1K_HUMAN (1-94): 3.07e-40: 134: 92.55
+	Hs
		555295 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1O_HUMAN (1-94): 4.25e-40: 134: 92.55
+	Hs
		555396 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1C_HUMAN (1-94): 4.74e-40: 134: 92.55
+	Hs
		555487 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B2E_HUMAN (1-94): 2.94e-40: 134: 93.62
+	Hs
		555496 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B2F_HUMAN (1-94): 7.09e-40: 134: 90.43
+	Hs
		555578 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1H_HUMAN (1-94): 6.79e-40: 134: 91.49
+	Hs
		555317 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1B_HUMAN (1-94): 1.18e-39: 133: 91.49
+	Hs
		555619 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1M_HUMAN (1-94): 1.42e-39: 133: 88.30
+	Hs
		555620 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1L_HUMAN (1-94): 1.1e-39: 133: 90.43
+	Hs
		555377 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1D_HUMAN (1-94): 1.66e-39: 132: 91.49
+	Hs
		555376 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2BFS_HUMAN (1-94): 9.65e-39: 131: 90.43
+	Hs
		555580 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2B1A_HUMAN (1-94): 6.61e-36: 123: 75.79
+	Hs
		1087366 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		H2B2E_HUMAN (1-94): 2.94e-40: 134: 93.62
+	Hs
		1274421 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		H2B1H_HUMAN (1-94): 6.79e-40: 134: 91.49
+	Hs
		241623 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		H2B1K_HUMAN (1-94): 3.07e-40: 134: 92.55
+	Hs
		1307102 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		H2B1M_HUMAN (1-94): 1.42e-39: 133: 88.30
+	Hs
		241601 H2A1C_HUMAN (1-129): 5.04e-66: 198: 92.25		H2B1K_HUMAN (1-94): 3.07e-40: 134: 92.55
+	Hs
		918580 H2A1C_HUMAN (1-129): 5.04e-66: 198: 92.25		H2B1C_HUMAN (1-94): 4.74e-40: 134: 92.55