HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: UBP49 (Q70CQ1)
Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49)
Gene: USP49

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35598681
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0042393 - histone binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 688
+	Hs
		271018 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		UBP2_HUMAN (55-659): 4e-109: 344: 19.50
+	Hs
		271104 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		UBP2_HUMAN (55-659): 4e-109: 344: 19.50
+	Hs
		777047 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		UBP8_HUMAN (109-660): 5.19e-103: 341: 19.27
+	Hs
		1087139 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		UBP20_HUMAN (2-678): 2.8e-97: 321: 17.75
+	Hs
		391971 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		UBP22_HUMAN (283-662): 9.54e-98: 312: 24.01
+	Hs
		555508 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		U17L2_HUMAN (307-686): 3.91e-89: 289: 20.05
+	Hs
		1087135 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		UBP22_HUMAN (283-662): 9.54e-98: 312: 24.01
+	Hs
		391756 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		UBP51_HUMAN (276-662): 5.38e-94: 308: 24.15
+	Hs
		1087027 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		UBP51_HUMAN (276-662): 5.38e-94: 308: 24.15
+	Hs
		391943 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		UBP36_HUMAN (153-685): 9.16e-88: 299: 20.37
+	Hs
		1151394 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		UBP21_HUMAN (312-655): 2e-91: 297: 22.69
+	Hs
		1312240 H2AJ_HUMAN (1-125): 5.62e-65: 195: 93.60		UBP36_HUMAN (153-685): 9.16e-88: 299: 20.37
+	Hs
		261028 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		UBP36_HUMAN (153-685): 9.16e-88: 299: 20.37
+	Hs
		905382 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		UBP46_HUMAN (296-658): 2.05e-93: 295: 23.12
+	Hs
		259285 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		UBP12_HUMAN (279-658): 1.04e-92: 294: 22.39
+	Sc
		392501 H2A2_YEAST (16-124): 4.61e-53: 165: 82.57		UBP8_YEAST (249-660): 5.53e-89: 287: 27.58
+	Hs
		391991 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		UBP3_HUMAN (4-160): 5.8e-25: 111: 23.08