HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: HDGR2 (Q7Z4V5)
Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)
Gene: HDGFL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 26721387
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 671
+	Hs
		260919 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		HDGR2_HUMAN (1-671): 9.52e-82: 274: 100.00
+	Hs
		331860 H2A1C_HUMAN (1-129): 5.04e-66: 198: 92.25		NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70
+	Hs
		331703 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70
+	Hs
		331824 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70
+	Hs
		261003 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		NSD3_HUMAN (4-413): 2.6e-62: 227: 11.66
+	Mm
		650197 H2AX_MOUSE (1-143): 1.9e-73: 217: 97.20		PSIP1_MOUSE (1-553): 5.28e-57: 203: 24.64
+	Hs
		555365 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		260680 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		PSIP1_HUMAN (1-553): 1.35e-54: 197: 23.49
+	Hs
		555690 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24
+	Hs
		855539 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		260808 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		391965 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24
+	Hs
		261039 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24
+	Hs
		391730 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		GLYR1_HUMAN (6-212): 3.25e-36: 145: 21.10
+	Hs
		555503 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		NIPBL_HUMAN (100-662): 1.42e-17: 89.7: 16.10
+	Hs
		260805 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		HDGF_HUMAN (3-234): 8.81e-26: 108: 35.78