HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: EYA1 (Q99502)
Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48)
Gene: EYA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	27795300, 19234442
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006302 - double-strand break repair GO:0010212 - response to ionizing radiation GO:0045739 - positive regulation of DNA repair
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 592
+	Hs
		555613 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		EYA3_HUMAN (41-592): 1.55e-159: 470: 50.99
+	Mm
		101453 H2A3_MOUSE (1-129): 5.88e-66: 197: 91.47		F8VPR5_MOUSE (4-323): 6.16e-22: 103: 13.98
+	Hs
		123844 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		SPT5H_HUMAN (4-129): 1.43e-09: 63.4: 14.84
+	Hs
		555298 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RPB1_HUMAN (90-285): 4.06e-09: 61.9: 14.54
+	Hs
		391802 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		KMT2C_HUMAN (21-304): 4.57e-10: 64.9: 13.84
+	Hs
		391610 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		SC24C_HUMAN (1-266): 8.04e-10: 64.2: 17.15
+	Hs
		123831 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		SPT5H_HUMAN (4-129): 1.43e-09: 63.4: 14.84
+	Hs
		391823 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CBP_HUMAN (52-326): 3.34e-09: 62.2: 11.64