HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: PARP2 (Q9UGN5)
Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)
Gene: PARP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006302 - double-strand break repair GO:0006974 - DNA damage response and 1 others more... GO:0090734 - site of DNA damage
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 583
+	Hs
		1151393 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		PARP2_HUMAN (16-583): 0: 739: 100.00
+	Hs
		391953 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		PARP2_HUMAN (16-583): 0: 739: 100.00
+	Hs
		470599 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		PARP2_HUMAN (16-583): 0: 739: 100.00
+	Hs
		1087127 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		PARP2_HUMAN (16-583): 0: 739: 100.00
+	Hs
		455054 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455802 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455622 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455732 H2A1C_HUMAN (1-129): 5.04e-66: 198: 92.25		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		391516 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455012 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455554 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455818 H2AJ_HUMAN (1-125): 5.62e-65: 195: 93.60		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		260727 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Dm
		728986 H2A_DROME (17-124): 3.82e-60: 183: 90.74		PARP_DROME (53-579): 0: 599: 38.80
+	Hs
		260693 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		TNKS1_HUMAN (294-577): 4.32e-59: 215: 20.24