HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	9234717, 30057274
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0005929 - cilium GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1089 Hs			1 906
+	Hs
		452353 PGFRB_HUMAN (29-1089): 0: 650: 43.33		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		499234 KIT_HUMAN (18-978): 0: 559: 33.64		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		403532 KIT_MOUSE (18-994): 0: 571: 33.43		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		452407 PGFRB_HUMAN (29-1089): 0: 650: 43.33		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		610268 FLT3_HUMAN (4-979): 1e-158: 498: 27.84		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		499262 KIT_HUMAN (18-978): 0: 559: 33.64		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		572586 VGFR1_HUMAN (18-659): 1.85e-51: 200: 18.22		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610266 VGFR2_HUMAN (7-588): 8.16e-51: 198: 17.81		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		601457 FGFR2_HUMAN (6-339): 9.02e-49: 189: 14.90		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610553 VGFR1_MOUSE (2-786): 3.83e-57: 218: 9.92		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		434137 RET_HUMAN (573-690): 7.85e-22: 104: 43.22		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		607879 FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		404008 PGFRB_MOUSE (4-571): 7.37e-24: 111: 11.66		CBL_MOUSE (1-906): 0: 888: 91.59
+	Rn
		88770 RET_RAT (573-690): 8.48e-23: 107: 44.07		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Dm
		112207 M9MRE1_DROME (20-534): 4.38e-44: 176: 17.11		O46034_DROME (47-460): 0: 746: 70.84
+	Hs
		607956 FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		434308 RET_HUMAN (573-690): 7.85e-22: 104: 43.22		CBLC_HUMAN (42-504): 0: 620: 42.07
+	Hs
		608187 FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36		CBLC_HUMAN (42-504): 0: 620: 42.07
+	Hs
		729657 VGFR2_HUMAN (7-588): 8.16e-51: 198: 17.81		MDC1_HUMAN (450-878): 1.89e-11: 70.3: 9.33
+	Hs
		608028 FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36		PHLB1_HUMAN (503-868): 1.01e-10: 68: 9.74