HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: SHF (Q7M4L6)
SH2 domain-containing adapter protein F
Gene: SHF

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	11095946
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1089 Hs			1 423
+	Mm
		643644 PGFRA_MOUSE (1-1089): 0: 819: 91.83		SHB_MOUSE (36-423): 5.71e-50: 178: 41.46
+	Hs
		557029 PGFRA_HUMAN (1-1089): 0: 817: 100.00		PLCG1_HUMAN (93-423): 4.63e-42: 160: 17.23
+	Rn
		595729 PGFRA_RAT (7-1089): 0: 811: 91.04		LYN_RAT (226-421): 1.25e-45: 166: 17.24
+	Hs
		557088 PGFRA_HUMAN (1-1089): 0: 817: 100.00		GRB2_HUMAN (316-401): 3.1e-22: 96.2: 32.18
+	Hs
		208979 PGFRB_HUMAN (29-1089): 0: 650: 43.33		NCK2_HUMAN (87-419): 8.3e-60: 201: 20.12
+	Hs
		433221 PGFRB_HUMAN (29-1089): 0: 650: 43.33		YES_HUMAN (169-414): 8.67e-57: 197: 18.18
+	Hs
		452344 PGFRB_HUMAN (29-1089): 0: 650: 43.33		NCK1_HUMAN (87-418): 4.28e-53: 183: 18.95
+	Hs
		411953 PGFRB_HUMAN (29-1089): 0: 650: 43.33		FYN_HUMAN (172-420): 1.05e-49: 178: 15.56
+	Hs
		452338 PGFRB_HUMAN (29-1089): 0: 650: 43.33		SRC_HUMAN (172-414): 1.03e-49: 178: 15.81
+	Hs
		145969 PGFRB_HUMAN (29-1089): 0: 650: 43.33		SH2B2_HUMAN (18-421): 1.26e-46: 171: 13.54
+	Hs
		452370 PGFRB_HUMAN (29-1089): 0: 650: 43.33		ABL2_HUMAN (162-420): 4.61e-43: 163: 20.00
+	Hs
		452348 PGFRB_HUMAN (29-1089): 0: 650: 43.33		PLCG1_HUMAN (93-423): 4.63e-42: 160: 17.23
+	Hs
		452364 PGFRB_HUMAN (29-1089): 0: 650: 43.33		SHC1_HUMAN (199-422): 2.17e-35: 139: 19.26
+	Hs
		452385 PGFRB_HUMAN (29-1089): 0: 650: 43.33		GRB2_HUMAN (316-401): 3.1e-22: 96.2: 32.18
+	Hs
		337317 PGFRB_HUMAN (29-1089): 0: 650: 43.33		ABL1_HUMAN (308-401): 7.81e-16: 81.9: 32.98
+	Mm
		403545 KIT_MOUSE (18-994): 0: 571: 33.43		SOCS6_MOUSE (10-420): 1.14e-42: 159: 18.63
+	Mm
		403530 KIT_MOUSE (18-994): 0: 571: 33.43		FES_MOUSE (129-420): 4.49e-38: 148: 20.75
+	Mm
		403533 KIT_MOUSE (18-994): 0: 571: 33.43		P85A_MOUSE (87-420): 7.1e-38: 147: 16.81
+	Mm
		403541 KIT_MOUSE (18-994): 0: 571: 33.43		GRB2_MOUSE (316-401): 3.1e-22: 96.2: 32.18
+	Mm
		292679 KIT_MOUSE (18-994): 0: 571: 33.43		GRAP2_MOUSE (316-401): 1.46e-16: 81.9: 30.23