HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1342
+	Hs
		208992 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		557701 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383587 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		208972 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337883 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		208970 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337337 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Mm
		337637 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		ABL1_MOUSE (696-1296): 5.65e-125: 417: 22.21
+	Mm
		222878 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		ACK1_MOUSE (677-1328): 5.23e-124: 413: 21.75
+	Hs
		434130 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		557644 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EPHB1_HUMAN (644-993): 1.32e-118: 396: 27.87
+	Hs
		208976 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		435526 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		208996 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		557670 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73
+	Hs
		557630 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		557666 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		209001 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		209000 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		TXK_HUMAN (707-969): 2.69e-44: 171: 37.12
+	Rn
		88904 D4A3M8_RAT (1-376): 3.92e-90: 277: 66.93		INSR_RAT (329-650): 1.42e-20: 101: 16.71