HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: CNTFR (P26992)
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Gene: CNTFR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005102 - signaling receptor binding GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 372
+	Hs
		500941 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		GHR_HUMAN (110-300): 2.28e-42: 158: 18.54
+	Hs
		235234 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31
+	Hs
		208961 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31
+	Hs
		234472 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DSCAM_HUMAN (54-356): 1.25e-12: 71.4: 12.58
+	Hs
		557632 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DCC_HUMAN (108-299): 1.66e-12: 71: 15.92
+	Hs
		208998 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64
+	Hs
		560468 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		PRLR_HUMAN (106-324): 1.04e-51: 183: 21.68
+	Hs
		500948 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		GHR_HUMAN (110-300): 2.28e-42: 158: 18.54
+	Hs
		129180 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		GHR_HUMAN (110-300): 2.28e-42: 158: 18.54
+	Hs
		235231 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31
+	Hs
		674354 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64
+	Hs
		412016 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		PTPRD_HUMAN (58-341): 1.32e-15: 80.7: 10.10
+	Hs
		655230 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64
+	Hs
		129215 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64
+	Mm
		643079 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		UFO_MOUSE (4-342): 1.19e-12: 71.4: 16.18
+	Hs
		655246 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		IL6RB_HUMAN (55-302): 3e-12: 70.2: 14.17
+	Mm
		140060 P85B_MOUSE (252-376): 2.57e-21: 97.5: 24.41		UFO_MOUSE (4-342): 1.19e-12: 71.4: 16.18
+	Mm
		56907 FYN_MOUSE (7-173): 7.13e-21: 96: 15.39		PTPRF_MOUSE (70-341): 7.24e-13: 72.2: 9.19
+	Hs
		411959 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		PTPRF_HUMAN (70-341): 2.76e-11: 67.2: 8.83
+	Mm
		643058 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		IL2RG_MOUSE (112-309): 5.64e-10: 62.1: 17.31