HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: PTN4 (P29074)
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
Gene: PTPN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 926
+	Hs
		655218 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		PTN4_HUMAN (1-926): 0: 949: 100.00
+	Hs
		412035 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		PTN4_HUMAN (1-926): 0: 949: 100.00
+	Hs
		208991 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45
+	Hs
		616906 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		PTPRB_HUMAN (334-925): 1.77e-123: 415: 23.64
+	Hs
		412416 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		E41L3_HUMAN (21-682): 1.53e-132: 427: 27.22
+	Hs
		655223 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46
+	Hs
		412016 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		PTPRD_HUMAN (348-912): 2e-97: 338: 21.33
+	Hs
		576988 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45
+	Rn
		1144045 FYN_RAT (7-173): 7.13e-21: 96: 15.39		Q66HJ7_RAT (639-912): 1.14e-95: 321: 33.45
+	Hs
		411997 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45
+	Mm
		574000 FYN_MOUSE (7-173): 7.13e-21: 96: 15.39		PTPRA_MOUSE (639-912): 1.11e-95: 321: 33.45
+	Rn
		1146020 SRC_RAT (5-114): 1.36e-15: 80.1: 22.32		Q66HJ7_RAT (639-912): 1.14e-95: 321: 33.45
+	Mm
		403413 SRC_MOUSE (5-114): 1.55e-15: 79.7: 22.32		PTPRA_MOUSE (639-912): 1.11e-95: 321: 33.45
+	Hs
		522756 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45
+	Rn
		976063 SRC_RAT (5-114): 1.36e-15: 80.1: 22.32		PTPRA_RAT (639-912): 8.98e-93: 312: 33.45
+	Hs
		788993 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		PTPRK_HUMAN (643-914): 1.01e-55: 212: 27.72
+	Hs
		617085 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		PTPRG_HUMAN (671-917): 8.47e-50: 193: 23.74
+	Hs
		655375 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		PTPRK_HUMAN (643-914): 1.01e-55: 212: 27.72
+	Rn
		94284 FYN_RAT (7-173): 7.13e-21: 96: 15.39		F1LXJ9_RAT (649-914): 3.89e-55: 210: 28.21
+	Hs
		412018 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		PTPRZ_HUMAN (565-912): 7.52e-53: 203: 20.44