HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 310
+	Hs
		557622 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92
+	Hs
		557704 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		MYLK_HUMAN (49-129): 7.38e-12: 68.3: 13.83
+	Hs
		209143 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		FCRL2_HUMAN (52-217): 1.22e-13: 72.9: 19.89
+	Dm
		219806 NCK_DROME (5-374): 5.6e-68: 225: 42.54		O44924_DROME (2-167): 3.27e-25: 107: 16.11
+	Hs
		412047 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00
+	Hs
		522811 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00
+	Hs
		412048 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92
+	Hs
		519366 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		FCG2A_HUMAN (38-310): 3.57e-58: 191: 73.29
+	Hs
		522812 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92
+	Hs
		789014 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		TUTLB_HUMAN (2-304): 6.34e-33: 130: 15.73
+	Hs
		519376 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		FCG2A_HUMAN (38-310): 3.57e-58: 191: 73.29
+	Hs
		523211 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		TUTLB_HUMAN (2-304): 6.34e-33: 130: 15.73
+	Mm
		643060 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		CD22_MOUSE (3-308): 2.01e-25: 108: 14.96
+	Mm
		722901 GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03		CD22_MOUSE (3-308): 2.01e-25: 108: 14.96
+	Hs
		442771 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		FCGR1_HUMAN (5-285): 9.76e-21: 92.9: 12.25
+	Hs
		655385 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		MYLK_HUMAN (49-129): 7.38e-12: 68.3: 13.83
+	Hs
		590600 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		CD22_HUMAN (92-310): 1.59e-09: 60.9: 13.33
+	Hs
		523003 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		MYLK_HUMAN (49-129): 7.38e-12: 68.3: 13.83
+	Hs
		519400 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		FCERA_HUMAN (2-133): 1.62e-12: 68.2: 16.06
+	Hs
		590607 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		CD22_HUMAN (92-310): 1.59e-09: 60.9: 13.33