HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22267732
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 635
+	Hs
		557644 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EPHB1_HUMAN (218-632): 1.32e-117: 375: 27.87
+	Hs
		557643 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EPHA5_HUMAN (171-632): 5.04e-115: 370: 25.42
+	Rn
		71362 B2RZ33_RAT (1-377): 8.61e-99: 300: 99.20		NTRK2_RAT (164-631): 5.57e-116: 367: 23.96
+	Hs
		507832 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		557707 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NTRK2_HUMAN (158-631): 7.36e-116: 366: 24.27
+	Hs
		208983 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		208996 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83
+	Hs
		411986 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Mm
		763403 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		FYN_MOUSE (4-201): 6.63e-69: 235: 22.03
+	Mm
		337637 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		ABL1_MOUSE (4-384): 1.19e-58: 215: 16.75
+	Hs
		337337 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ABL1_HUMAN (4-385): 1.81e-58: 214: 17.07
+	Hs
		557666 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FAK1_HUMAN (344-626): 1.88e-57: 211: 39.30
+	Hs
		557701 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ERBB4_HUMAN (375-619): 7.14e-57: 210: 43.15
+	Hs
		337883 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		557630 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ABL2_HUMAN (4-193): 3.72e-56: 207: 19.54
+	Hs
		383587 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		208970 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		209001 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ABL2_HUMAN (4-193): 3.72e-56: 207: 19.54
+	Hs
		208972 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		209000 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		TXK_HUMAN (15-201): 5.99e-17: 86.1: 22.90