HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: TNFL6 (P48023)
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Gene: FASLG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 0.60 0.697

The method score is based on:

Property Details
Experiments 26871637, 11741599, 19807924, 16595635
Identification Methods two hybrid, pull down, unspecified method, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, phage display
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005102 - signaling receptor binding
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 377
Hs

1 281
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Last updated: 15 Jul 2024