HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: PAXI (P49023)
Paxillin
Gene: PXN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10330411
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0007165 - signal transduction GO:0007172 - signal complex assembly and 1 others more... GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 591
+	Hs
		209008 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		788979 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		789046 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Mm
		1113253 SRBS2_MOUSE (46-288): 1.38e-24: 107: 18.85		PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62
+	Hs
		412085 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		442793 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		522857 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		823365 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		209005 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97
+	Mm
		403454 SRC_MOUSE (5-114): 1.55e-15: 79.7: 22.32		PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62
+	Hs
		782755 CSK_HUMAN (4-143): 1.92e-12: 70.2: 14.38		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		442845 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		FHL5_HUMAN (381-590): 9.47e-63: 210: 29.44
+	Hs
		200163 CSK_HUMAN (4-143): 1.92e-12: 70.2: 14.38		TGFI1_HUMAN (1-532): 4.62e-63: 216: 24.91
+	Hs
		300996 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		ABLM3_HUMAN (416-590): 1.41e-40: 158: 29.03
+	Hs
		924889 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90
+	Hs
		111447 J3QRU1_HUMAN (112-218): 4.03e-11: 66.5: 19.27		PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90
+	Hs
		442827 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87
+	Hs
		782788 CSK_HUMAN (4-143): 1.92e-12: 70.2: 14.38		FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87
+	Hs
		254384 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		LDB3_HUMAN (474-590): 4.47e-13: 74.3: 33.33
+	Hs
		150552 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32