HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: DAB2 (P98082)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Gene: DAB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 770
+	Mm
		956235 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Hs
		269120 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62
+	Hs
		209098 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ANS1B_HUMAN (12-227): 1.36e-43: 172: 19.01
+	Mm
		223010 NCK2_MOUSE (1-376): 3.75e-90: 277: 66.93		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Hs
		208964 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62
+	Hs
		655317 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Hs
		412132 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Hs
		203208 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64
+	Hs
		454823 FGR_HUMAN (7-150): 8.06e-20: 92.9: 20.00		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Mm
		957157 ITSN1_MOUSE (5-286): 2.38e-17: 85.9: 17.19		DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15
+	Hs
		655522 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		NUMBL_HUMAN (18-585): 6.55e-41: 161: 13.54
+	Mm
		763385 FYN_MOUSE (7-173): 7.13e-21: 96: 15.39		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Mm
		956225 YES_MOUSE (5-201): 6.24e-20: 93.2: 16.42		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Mm
		1206702 ITSN1_MOUSE (5-286): 2.38e-17: 85.9: 17.19		ANS1B_MOUSE (12-230): 5.35e-41: 164: 18.67
+	Hs
		655498 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		DP13A_HUMAN (15-259): 1.71e-36: 148: 11.91
+	Hs
		129347 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		DP13A_HUMAN (15-259): 1.71e-36: 148: 11.91
+	Hs
		253524 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		CAPON_HUMAN (19-299): 8.52e-35: 141: 13.91
+	Hs
		203192 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64
+	Hs
		203230 SH319_HUMAN (8-254): 6.26e-19: 90.5: 19.84		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64
+	Hs
		203228 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64