HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25218436
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030971 - receptor tyrosine kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 982
+	Hs
		209046 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Mm
		82738 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		B9EKI5_MOUSE (1-982): 0: 852: 90.53
+	Mm
		223012 NCK2_MOUSE (1-376): 3.75e-90: 277: 66.93		CBLB_MOUSE (1-982): 0: 873: 95.12
+	Hs
		298976 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		655351 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		129289 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		557607 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		610633 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		208994 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		610281 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		610595 SRBS2_MOUSE (46-288): 1.38e-24: 107: 18.85		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		298949 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		610238 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		610546 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		129202 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		140057 P85B_MOUSE (252-376): 2.57e-21: 97.5: 24.41		CBL_MOUSE (25-976): 0: 674: 47.47
+	Rn
		88780 P85A_RAT (241-376): 8.21e-22: 99.1: 19.57		D3ZV15_RAT (25-931): 0: 647: 48.11
+	Hs
		203208 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Hs
		203192 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Rn
		192744 SRBS2_RAT (3-162): 4.86e-25: 109: 28.05		SYNJ1_RAT (687-978): 9.27e-09: 62: 10.51