HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: ADA15 (Q13444)
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
Gene: ADAM15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	16374509, 18296648
Identification Methods	pull down, affinity chromatography technology, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 863
+	Hs
		557788 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		788990 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		298978 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		655355 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		788989 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00
+	Hs
		412180 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		789007 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		442824 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		788983 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		ADAM8_HUMAN (1-851): 5.57e-160: 489: 31.26
+	Hs
		298977 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00
+	Hs
		152249 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		197589 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		197579 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		655459 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		197581 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		442882 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		314542 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		ATS2_HUMAN (14-704): 1.28e-101: 344: 19.00
+	Hs
		152285 GRAP_HUMAN (5-251): 9.35e-27: 107: 20.00		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152228 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152233 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44