HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: DOCK1 (Q14185)
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Gene: DOCK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1865
+	Hs
		209053 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		412190 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Mm
		1141146 GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03		DOCK1_MOUSE (1-1865): 0: 2189: 96.46
+	Hs
		522979 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		924565 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		557736 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		924868 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		DOCK5_HUMAN (1-1844): 0: 1934: 62.63
+	Hs
		655417 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		412257 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		523056 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		924695 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		1078864 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		DOCK4_HUMAN (4-1855): 0: 1748: 36.35
+	Hs
		924698 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		DOCK4_HUMAN (4-1855): 0: 1748: 36.35
+	Hs
		523071 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		DOCK8_HUMAN (707-1086): 1.69e-39: 164: 9.09
+	Hs
		496365 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		411960 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		496189 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		496788 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		924760 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		PRG4_HUMAN (1634-1856): 2.09e-09: 65.2: 13.39
+	Hs
		1056926 SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76		MDC1_HUMAN (1604-1861): 7.61e-10: 66.7: 16.67