HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 2725
+	Hs
		655367 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		412192 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		261193 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		298948 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		597968 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		412006 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		522770 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		261205 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Mm
		1113251 SRBS2_MOUSE (46-288): 1.38e-24: 107: 18.85		ACTN1_MOUSE (13-382): 1.48e-122: 413: 26.30
+	Hs
		298946 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		211443 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Ce
		87673 Q95PW9_CAEEL (1-376): 2.62e-70: 227: 38.69		D0IMZ6_CAEEL (1303-2127): 1.07e-75: 273: 22.61
+	Hs
		521454 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		211480 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		211557 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		129277 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		963335 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		1078871 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		SYNE1_HUMAN (33-344): 6.35e-100: 364: 28.65
+	Ce
		87661 Q95PW9_CAEEL (1-376): 2.62e-70: 227: 38.69		D0IMZ5_CAEEL (2126-2724): 6.74e-26: 120: 18.59
+	Hs
		362685 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83