HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: PKN2 (Q16513)
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
Gene: PKN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	8910519, 10026169
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction and 1 others more... GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 984
+	Hs
		209064 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		PKN2_HUMAN (1-984): 0: 1145: 97.99
+	Dm
		52733 SRC42_DROME (6-127): 2.31e-18: 88.3: 24.19		PKN_DROME (40-984): 2.09e-127: 417: 33.81
+	Dm
		52725 GRAP_DROME (1-61): 1.53e-17: 82.3: 31.15		PKN_DROME (40-984): 2.09e-127: 417: 33.81
+	Hs
		655279 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		KS6A3_HUMAN (442-929): 3.75e-111: 362: 22.16
+	Hs
		412095 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		KS6A3_HUMAN (442-929): 3.75e-111: 362: 22.16
+	Hs
		412145 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		KPCD_HUMAN (653-980): 1.78e-96: 321: 47.42
+	Hs
		655378 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		KS6A2_HUMAN (569-965): 2.87e-89: 303: 25.00
+	Hs
		129296 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		KS6A2_HUMAN (569-965): 2.87e-89: 303: 25.00
+	Hs
		412203 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		KS6A2_HUMAN (569-965): 2.87e-89: 303: 25.00
+	Hs
		412205 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		KS6A1_HUMAN (571-920): 1.64e-86: 295: 27.52
+	Hs
		789116 FRK_HUMAN (3-127): 1.77e-17: 85.6: 22.39		KS6A1_HUMAN (571-920): 1.64e-86: 295: 27.52
+	Hs
		616675 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		KS6B1_HUMAN (397-670): 1.04e-27: 120: 12.04
+	Hs
		298951 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		AKT2_HUMAN (364-610): 4.79e-17: 87.5: 10.84
+	Mm
		643056 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		AKT1_MOUSE (397-605): 1.55e-17: 88.6: 11.16
+	Hs
		655233 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70
+	Hs
		129308 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		PKN3_HUMAN (12-215): 6.12e-17: 88.2: 20.69
+	Hs
		412046 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70
+	Mm
		554895 P70304_MOUSE (241-376): 2.17e-22: 101: 19.57		KPCE_MOUSE (397-485): 2.05e-14: 79.7: 14.61
+	Mm
		643082 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		KPCT_MOUSE (397-560): 1.76e-14: 79.7: 13.33
+	Hs
		412141 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		KPCT_HUMAN (397-567): 7.7e-15: 80.9: 13.37