HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: Q5JSD8 (Q5JSD8)
Rho GTPase activating protein 21
Gene: ARHGAP21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 113
+	Hs
		557714 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		RHG21_HUMAN (1-112): 1.02e-40: 144: 91.30
+	Hs
		64651 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		RHG32_HUMAN (2-112): 9.38e-39: 139: 25.44
+	Hs
		557642 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		CHIO_HUMAN (3-112): 9.79e-39: 136: 34.51
+	Hs
		551038 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		CHIN_HUMAN (3-112): 2.56e-37: 132: 37.17
+	Hs
		64627 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		RHG32_HUMAN (2-112): 9.38e-39: 139: 25.44
+	Hs
		209014 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		CHIO_HUMAN (3-112): 9.79e-39: 136: 34.51
+	Hs
		208987 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		CHIN_HUMAN (3-112): 2.56e-37: 132: 37.17
+	Hs
		64658 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RHG32_HUMAN (2-112): 9.38e-39: 139: 25.44
+	Hs
		64642 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		RHG32_HUMAN (2-112): 9.38e-39: 139: 25.44
+	Mm
		763398 FYN_MOUSE (7-173): 7.13e-21: 96: 15.39		RHG33_MOUSE (2-112): 4.76e-38: 137: 27.19
+	Hs
		147859 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		RHG33_HUMAN (2-112): 5.09e-38: 136: 27.19
+	Hs
		506586 GRAP_HUMAN (5-251): 9.35e-27: 107: 20.00		BCR_HUMAN (2-111): 1.52e-33: 124: 34.51
+	Hs
		655460 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RGAP1_HUMAN (2-113): 8.65e-36: 130: 30.44
+	Hs
		506520 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		BCR_HUMAN (2-111): 1.52e-33: 124: 34.51
+	Mm
		64329 ITSN1_MOUSE (5-286): 2.38e-17: 85.9: 17.19		RHG31_MOUSE (2-112): 2.28e-38: 137: 25.44
+	Hs
		129182 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		BCR_HUMAN (2-111): 1.52e-33: 124: 34.51
+	Hs
		1078833 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		RHG31_HUMAN (2-112): 4.29e-38: 137: 25.44
+	Hs
		442768 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		BCR_HUMAN (2-111): 1.52e-33: 124: 34.51
+	Mm
		1145001 ITSN1_MOUSE (5-286): 2.38e-17: 85.9: 17.19		RHG30_MOUSE (2-112): 3.24e-35: 129: 28.07
+	Hs
		506538 FRK_HUMAN (3-127): 1.77e-17: 85.6: 22.39		BCR_HUMAN (2-111): 1.52e-33: 124: 34.51