HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: Q6NSK7 (Q6NSK7)
RIN3 protein
Gene: RIN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	unassigned1973
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 908
+	Hs
		557745 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		RIN3_HUMAN (1-908): 0: 597: 89.04
+	Hs
		70370 B2R6S4_HUMAN (1-377): 3.34e-98: 298: 99.74		RIN3_HUMAN (1-908): 0: 597: 89.04
+	Hs
		1078842 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		Q6NSK7_HUMAN (1-908): 0: 678: 100.00
+	Hs
		1155937 ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05		Q6NSK7_HUMAN (1-908): 0: 678: 100.00
+	Hs
		412275 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		RIN3_HUMAN (1-908): 0: 597: 89.04
+	Hs
		523075 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		RIN3_HUMAN (1-908): 0: 597: 89.04
+	Hs
		69536 B0LPF3_HUMAN (3-61): 2.12e-16: 79.1: 28.81		RIN3_HUMAN (1-908): 0: 597: 89.04
+	Hs
		924717 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		RIN3_HUMAN (1-908): 0: 597: 89.04
+	Hs
		1251932 ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05		RIN3_HUMAN (1-908): 0: 597: 89.04
+	Hs
		203208 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SYNJ1_HUMAN (103-493): 8.16e-10: 65.2: 14.14
+	Rn
		192744 SRBS2_RAT (3-162): 4.86e-25: 109: 28.05		SYNJ1_RAT (153-642): 1.6e-44: 177: 15.79
+	Hs
		789065 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		RIN1_HUMAN (2-559): 3.8e-37: 152: 20.18
+	Hs
		1044770 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		RIN1_HUMAN (2-559): 3.8e-37: 152: 20.18
+	Hs
		655419 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		TENS4_HUMAN (7-158): 1.34e-29: 128: 16.46
+	Hs
		924632 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		TENS2_HUMAN (3-217): 4.89e-32: 137: 19.33
+	Hs
		523025 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		TENS3_HUMAN (26-185): 2.03e-29: 128: 15.08
+	Hs
		203192 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SYNJ1_HUMAN (103-493): 8.16e-10: 65.2: 14.14
+	Hs
		203230 SH319_HUMAN (8-254): 6.26e-19: 90.5: 19.84		SYNJ1_HUMAN (103-493): 8.16e-10: 65.2: 14.14
+	Hs
		203228 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		SYNJ1_HUMAN (103-493): 8.16e-10: 65.2: 14.14
+	Hs
		203218 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		SYNJ1_HUMAN (103-493): 8.16e-10: 65.2: 14.14