HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: LMTK1 (Q6ZMQ8)
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)
Gene: AATK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1374
+	Hs
		557670 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ACK1_HUMAN (54-854): 2.25e-146: 474: 21.51
+	Hs
		209039 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ACK1_HUMAN (54-854): 2.25e-146: 474: 21.51
+	Mm
		337637 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		ABL1_MOUSE (113-878): 1.89e-124: 416: 19.42
+	Mm
		222878 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		ACK1_MOUSE (55-976): 4.88e-124: 413: 20.25
+	Hs
		557644 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EPHB1_HUMAN (6-505): 2.12e-123: 410: 19.80
+	Hs
		507832 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FGFR1_HUMAN (28-460): 6.26e-120: 396: 21.00
+	Hs
		208983 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		FGFR1_HUMAN (28-460): 6.26e-120: 396: 21.00
+	Hs
		557705 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NTRK3_HUMAN (24-398): 5.5e-110: 369: 25.54
+	Hs
		557643 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EPHA5_HUMAN (12-404): 9.44e-107: 365: 22.68
+	Rn
		71362 B2RZ33_RAT (1-377): 8.61e-99: 300: 99.20		NTRK2_RAT (30-400): 2.03e-106: 359: 28.03
+	Hs
		557707 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NTRK2_HUMAN (30-400): 4.89e-106: 357: 27.78
+	Hs
		209063 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		NTRK3_HUMAN (24-398): 5.5e-110: 369: 25.54
+	Hs
		411986 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FYN_HUMAN (104-408): 1.36e-104: 344: 30.07
+	Hs
		209065 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		NTRK2_HUMAN (30-400): 4.89e-106: 357: 27.78
+	Hs
		435526 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		IGF1R_HUMAN (119-391): 2.65e-38: 159: 34.51
+	Hs
		384213 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NTRK1_HUMAN (120-398): 5.02e-34: 143: 32.77
+	Hs
		557826 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ALK_HUMAN (109-386): 2.69e-32: 139: 32.99
+	Rn
		88904 D4A3M8_RAT (1-376): 3.92e-90: 277: 66.93		INSR_RAT (111-395): 8.57e-39: 160: 35.25
+	Hs
		209000 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		TXK_HUMAN (125-391): 2.9e-32: 135: 33.83
+	Hs
		337337 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ABL1_HUMAN (588-1118): 4.91e-10: 66.4: 13.32