HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: H2B3B (Q8N257)
Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1)
Gene: H2BC26

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 126
+	Hs
		557845 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		U3KQK0_HUMAN (1-126): 4.33e-56: 173: 96.03
+	Hs
		557647 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		H2B1D_HUMAN (1-126): 4.1e-54: 167: 95.24
+	Hs
		924623 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		H2B2F_HUMAN (1-126): 1.97e-55: 170: 95.24
+	Hs
		924770 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		H2B1H_HUMAN (1-126): 5.83e-55: 169: 96.03
+	Hs
		924820 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		H2B1M_HUMAN (1-126): 5.4e-55: 169: 92.86
+	Hs
		241496 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		H2B1K_HUMAN (1-126): 2.01e-54: 168: 94.44
+	Hs
		883010 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		H2BFS_HUMAN (1-126): 1.84e-54: 168: 92.86
+	Hs
		918279 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		H2B1C_HUMAN (1-126): 1.76e-54: 168: 95.24
+	Hs
		886077 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		H2B1D_HUMAN (1-126): 4.1e-54: 167: 95.24
+	Hs
		924819 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		H2B1N_HUMAN (1-126): 3.84e-54: 167: 96.03
+	Hs
		924821 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		H2B1L_HUMAN (1-126): 5.26e-53: 164: 95.24