HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: WIPF2 (Q8TF74)
WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)
Gene: WIPF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 440
+	Hs
		166030 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		557740 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		209127 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		WIPF2_HUMAN (1-440): 4.28e-32: 128: 100.00
+	Hs
		209112 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		62640 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Hs
		203208 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Hs
		209071 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		TGO1_HUMAN (104-359): 3.95e-21: 98.8: 22.71
+	Hs
		62638 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Ce
		712432 Q95PW9_CAEEL (1-376): 2.62e-70: 227: 38.69		SC161_CAEEL (125-438): 4.92e-18: 89.1: 15.90
+	Hs
		166032 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		166024 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		166049 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		203192 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Hs
		203230 SH319_HUMAN (8-254): 6.26e-19: 90.5: 19.84		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Hs
		62646 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Rn
		192744 SRBS2_RAT (3-162): 4.86e-25: 109: 28.05		SYNJ1_RAT (1-430): 2.86e-12: 71: 11.97
+	Hs
		203228 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Hs
		655524 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		MYO16_HUMAN (3-288): 2.53e-10: 64.9: 14.00
+	Hs
		412433 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		MYO16_HUMAN (3-288): 2.53e-10: 64.9: 14.00
+	Hs
		522749 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		MUC1_HUMAN (142-437): 6.35e-11: 66.8: 11.15