HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: RPGF5 (Q92565)
Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)
Gene: RAPGEF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	8561895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 580
+	Hs
		557669 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SOS2_HUMAN (48-579): 3.62e-92: 310: 14.18
+	Hs
		557683 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Hs
		557668 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Hs
		209038 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Hs
		557709 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		RGPS1_HUMAN (339-578): 2.69e-77: 256: 24.29
+	Dm
		644374 SRC42_DROME (6-127): 2.31e-18: 88.3: 24.19		SOS_DROME (41-579): 2.87e-126: 407: 16.37
+	Dm
		644366 GRAP_DROME (1-61): 1.53e-17: 82.3: 31.15		SOS_DROME (41-579): 2.87e-126: 407: 16.37
+	Hs
		655333 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		SOS2_HUMAN (48-579): 3.62e-92: 310: 14.18
+	Hs
		412151 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		SOS2_HUMAN (48-579): 3.62e-92: 310: 14.18
+	Hs
		992475 GRAP_HUMAN (5-251): 9.35e-27: 107: 20.00		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Hs
		655361 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Hs
		655332 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Hs
		412185 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Hs
		992508 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		SOS2_HUMAN (48-579): 3.62e-92: 310: 14.18
+	Hs
		412150 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Hs
		442826 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Hs
		442816 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Hs
		992477 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Hs
		522934 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Dm
		284703 GRAP_DROME (1-61): 1.53e-17: 82.3: 31.15		C3G_DROME (340-579): 3.82e-72: 253: 24.90