HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007015 - actin filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 236
+	Hs
		557724 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		209093 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		209142 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		RHOV_HUMAN (1-236): 3.37e-76: 231: 100.00
+	Hs
		209021 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		655404 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		789055 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		789050 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564442 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545245 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		789051 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		655316 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		655443 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RHOV_HUMAN (1-236): 3.37e-76: 231: 100.00
+	Mm
		643072 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		RAC1_MOUSE (32-217): 3.34e-76: 230: 53.23
+	Hs
		655307 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		655294 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564419 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545215 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		655297 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Hs
		789092 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Hs
		655295 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39