HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: MINT (Q96T58)
Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)
Gene: SPEN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 3664
+	Hs
		655449 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		MINT_HUMAN (1-3664): 0: 1099: 100.00
+	Hs
		924808 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		MINT_HUMAN (1-3664): 0: 1099: 100.00
+	Hs
		557660 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ANK2_HUMAN (809-3143): 4.11e-25: 118: 9.30
+	Hs
		924473 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		MAP1A_HUMAN (1594-3632): 5.67e-29: 131: 8.94
+	Hs
		924484 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		ANK2_HUMAN (809-3143): 4.11e-25: 118: 9.30
+	Ce
		666211 SEM5_CAEEL (3-56): 7.02e-16: 78.1: 33.33		Q17350_CAEEL (215-437): 1.02e-16: 89.5: 11.89
+	Hs
		522960 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		PABP4_HUMAN (6-131): 2.64e-15: 84.9: 15.03
+	Hs
		523147 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		PABP3_HUMAN (215-439): 8.48e-13: 76.8: 11.89
+	Hs
		1302717 VAV3_HUMAN (1-58): 1.16e-12: 71.4: 24.59		RBM15_HUMAN (3336-3649): 5.22e-14: 81.1: 26.65
+	Hs
		433459 YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27		RBM15_HUMAN (3336-3649): 5.22e-14: 81.1: 26.65
+	Hs
		1031420 SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76		PABP4_HUMAN (6-131): 2.64e-15: 84.9: 15.03
+	Hs
		516342 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		PABP1_HUMAN (6-156): 2.77e-09: 65.2: 13.48
+	Hs
		516450 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		PABP1_HUMAN (6-156): 2.77e-09: 65.2: 13.48
+	Hs
		516629 SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76		PABP1_HUMAN (6-156): 2.77e-09: 65.2: 13.48