HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: NHSL3 (Q9P206)
NHS-like protein 3
Gene: NHSL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.560

Property	Details
Experiments	33961781, 21988832
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1035
+	Hs
		209183 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		NHSL3_HUMAN (1-1035): 9.42e-93: 320: 100.00
+	Hs
		1285208 SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76		NHSL3_HUMAN (1-1035): 9.42e-93: 320: 100.00
+	Hs
		203208 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SYNJ1_HUMAN (709-1032): 2.65e-11: 70.3: 13.78
+	Hs
		209017 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ATN1_HUMAN (61-1032): 4.58e-11: 69.3: 10.60
+	Ce
		712432 Q95PW9_CAEEL (1-376): 2.62e-70: 227: 38.69		SC161_CAEEL (503-790): 2.76e-10: 66.9: 20.41
+	Hs
		522749 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		MUC1_HUMAN (176-1033): 2.85e-50: 195: 15.55
+	Hs
		554292 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		MUC1_HUMAN (176-1033): 2.85e-50: 195: 15.55
+	Hs
		924760 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		PRG4_HUMAN (487-1035): 5.01e-20: 98.6: 13.22
+	Hs
		203192 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SYNJ1_HUMAN (709-1032): 2.65e-11: 70.3: 13.78
+	Hs
		412362 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		MAGE1_HUMAN (458-804): 3.64e-12: 72.7: 18.06
+	Hs
		203230 SH319_HUMAN (8-254): 6.26e-19: 90.5: 19.84		SYNJ1_HUMAN (709-1032): 2.65e-11: 70.3: 13.78
+	Hs
		924473 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		MAP1A_HUMAN (95-905): 1.99e-13: 77.4: 11.30
+	Hs
		203228 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		SYNJ1_HUMAN (709-1032): 2.65e-11: 70.3: 13.78
+	Hs
		1056926 SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76		MDC1_HUMAN (287-1032): 1.49e-17: 90.8: 12.39
+	Hs
		203218 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		SYNJ1_HUMAN (709-1032): 2.65e-11: 70.3: 13.78
+	Hs
		523118 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		CIC_HUMAN (204-973): 1.01e-09: 65.3: 10.88
+	Hs
		782820 CSK_HUMAN (4-143): 1.92e-12: 70.2: 14.38		CIC_HUMAN (204-973): 1.01e-09: 65.3: 10.88
+	Mm
		101430 CSK_MOUSE (4-143): 1.65e-12: 70.2: 14.38		F8VPR5_MOUSE (589-986): 1.29e-09: 65: 15.78
+	Hs
		257713 ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05		ANR17_HUMAN (216-864): 2.15e-09: 64.1: 15.14
+	Hs
		203241 SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76		SYNJ1_HUMAN (709-1032): 2.65e-11: 70.3: 13.78