HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: TNIK (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	32640226, 33961781, 10521462, 17474147
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, peptide array
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1360
+	Hs
		209186 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Hs
		557740 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		209112 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Mm
		949279 SRBS2_MOUSE (46-288): 1.38e-24: 107: 18.85		TNIK_MOUSE (1-1360): 0: 1208: 96.10
+	Hs
		324734 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		208968 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Mm
		956970 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		M4K4_MOUSE (1-1360): 0: 946: 58.91
+	Hs
		209164 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		SIK2_HUMAN (15-915): 3.97e-124: 410: 14.70
+	Hs
		557731 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		M4K3_HUMAN (13-371): 3.79e-108: 365: 40.33
+	Dm
		1182596 NCK_DROME (5-374): 5.6e-68: 225: 42.54		Q7KV88_DROME (3-772): 2.56e-123: 412: 41.74
+	Ce
		1095301 Q95PW9_CAEEL (1-376): 2.62e-70: 227: 38.69		MIG15_CAEEL (6-722): 1.6e-113: 385: 37.98
+	Hs
		557840 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38
+	Hs
		655378 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		129296 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Mm
		1113249 SRBS2_MOUSE (46-288): 1.38e-24: 107: 18.85		TAOK2_MOUSE (1-858): 2.53e-132: 440: 22.14
+	Hs
		655279 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		412095 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		655461 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		SIK2_HUMAN (15-915): 3.97e-124: 410: 14.70
+	Hs
		298951 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		AKT2_HUMAN (3-352): 5.78e-123: 392: 22.87
+	Hs
		412163 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		STK4_HUMAN (5-482): 7.72e-121: 387: 33.06