HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10391903
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 676
+	Hs
		557681 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		209049 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		1040322 GRAP_HUMAN (5-251): 9.35e-27: 107: 20.00		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		655510 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		129351 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Mm
		643089 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		Q3ZB59_MOUSE (1-676): 0: 714: 91.31
+	Mm
		140061 P85B_MOUSE (252-376): 2.57e-21: 97.5: 24.41		Q3ZB59_MOUSE (1-676): 0: 714: 91.31
+	Mm
		140067 P85B_MOUSE (252-376): 2.57e-21: 97.5: 24.41		GAB2_MOUSE (1-676): 0: 714: 91.16
+	Hs
		788991 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		655356 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		129290 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		442825 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		643113 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		522965 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		403466 SRC_MOUSE (5-114): 1.55e-15: 79.7: 22.32		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		412280 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		GAB3_HUMAN (3-667): 7.57e-162: 479: 31.42
+	Hs
		523086 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		GAB3_HUMAN (3-667): 7.57e-162: 479: 31.42
+	Hs
		209111 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		SESQ1_HUMAN (2-132): 1.35e-28: 116: 22.63
+	Dm
		993221 GRAP_DROME (1-61): 1.53e-17: 82.3: 31.15		DOS_DROME (8-218): 1.26e-36: 149: 30.22
+	Dm
		993229 GRAP_DROME (1-61): 1.53e-17: 82.3: 31.15		X2JFU3_DROME (9-119): 3.8e-24: 104: 24.32