HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: DLGP4 (Q9Y2H0)
Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4)
Gene: DLGAP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	32296183, 17474147, unassigned1304
Identification Methods	two hybrid, peptide array, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 992
+	Hs
		209192 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		DLGP4_HUMAN (1-992): 0: 1252: 100.00
+	Hs
		145936 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DLGP1_HUMAN (1-992): 0: 1167: 46.62
+	Hs
		557812 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DLGP2_HUMAN (1-992): 0: 1064: 43.22
+	Hs
		299006 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		DLGP4_HUMAN (1-992): 0: 1252: 100.00
+	Hs
		655514 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		DLGP4_HUMAN (1-992): 0: 1252: 100.00
+	Hs
		412415 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		DLGP4_HUMAN (1-992): 0: 1252: 100.00
+	Hs
		327225 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DLGP3_HUMAN (1-992): 0: 986: 35.35
+	Hs
		145930 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		DLGP1_HUMAN (1-992): 0: 1167: 46.62
+	Hs
		145939 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		DLGP1_HUMAN (1-992): 0: 1167: 46.62
+	Hs
		145934 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		DLGP1_HUMAN (1-992): 0: 1167: 46.62
+	Rn
		192741 SRBS2_RAT (3-162): 4.86e-25: 109: 28.05		DLGP1_RAT (1-992): 0: 1152: 46.00
+	Mm
		1113254 SRBS2_MOUSE (46-288): 1.38e-24: 107: 18.85		DLGP1_MOUSE (1-992): 0: 1144: 45.61
+	Hs
		145950 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		DLGP1_HUMAN (1-992): 0: 1167: 46.62
+	Hs
		145935 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		DLGP1_HUMAN (1-992): 0: 1167: 46.62
+	Hs
		655489 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		DLGP2_HUMAN (1-992): 0: 1064: 43.22
+	Hs
		412385 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		DLGP2_HUMAN (1-992): 0: 1064: 43.22
+	Hs
		523179 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		DLGP2_HUMAN (1-992): 0: 1064: 43.22
+	Hs
		327228 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		DLGP3_HUMAN (1-992): 0: 986: 35.35
+	Hs
		327222 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		DLGP3_HUMAN (1-992): 0: 986: 35.35
+	Hs
		327223 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		DLGP3_HUMAN (1-992): 0: 986: 35.35