HitPredict

Interactor 1: GROU (P16371)
Protein groucho (Enhancer of split m9/10 protein) (E(spl)m9/10)
Gene: gro

Interactor 2: ESMD (Q01071)
Enhancer of split mdelta protein (E(spl)mdelta) (HLH-mdelta) (Split locus enhancer protein mC)
Gene: E(spl)mdelta-HLH

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.734

Property	Details
Experiments	9371806, 16762837, 8001118, 9524128, 30995488, 14605208
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 730 Dm			1 173
+	Dm
		558370 GROU_DROME (1-730): 4.17e-172: 513: 100.00		ESMB_DROME (6-173): 3.64e-54: 171: 38.86
+	Dm
		558371 GROU_DROME (1-730): 4.17e-172: 513: 100.00		ESMC_DROME (1-173): 3.93e-54: 171: 37.07
+	Dm
		525718 GROU_DROME (1-730): 4.17e-172: 513: 100.00		ESM7_DROME (8-173): 6.28e-48: 155: 37.57
+	Dm
		558377 GROU_DROME (1-730): 4.17e-172: 513: 100.00		DPN_DROME (3-135): 2.59e-45: 155: 33.08
+	Dm
		534341 GROU_DROME (1-730): 4.17e-172: 513: 100.00		HAIR_DROME (3-173): 4.27e-44: 150: 30.99
+	Dm
		525743 GROU_DROME (1-730): 4.17e-172: 513: 100.00		ESM8_DROME (6-173): 6.16e-45: 147: 32.61
+	Dm
		558369 GROU_DROME (1-730): 4.17e-172: 513: 100.00		ESM3_DROME (7-165): 7.73e-42: 141: 34.88
+	Dm
		558409 GROU_DROME (1-730): 4.17e-172: 513: 100.00		Q9VWX7_DROME (1-173): 1.12e-41: 138: 23.76
+	Dm
		525705 GROU_DROME (1-730): 4.17e-172: 513: 100.00		ESM5_DROME (6-173): 1.43e-39: 134: 29.67
+	Dm
		558399 GROU_DROME (1-730): 4.17e-172: 513: 100.00		Q9VJ16_DROME (1-154): 4.77e-33: 124: 24.71
+	Hs
		980604 TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08		HES1_HUMAN (2-141): 1.35e-51: 168: 31.72
+	Hs
		980671 TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08		HEY1_HUMAN (6-172): 2e-44: 150: 20.00
+	Hs
		980651 TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08		HES4_HUMAN (2-173): 3.72e-45: 149: 24.38
+	Hs
		980948 TLE4_HUMAN (1-730): 4.44e-156: 473: 60.87		HES6_HUMAN (11-168): 1.14e-37: 130: 26.58
+	Hs
		980686 TLE2_HUMAN (1-730): 8.83e-141: 432: 55.91		HES1_HUMAN (2-141): 1.35e-51: 168: 31.72
+	Hs
		980638 TLE1_HUMAN (1-730): 6.59e-154: 467: 60.08		HES6_HUMAN (11-168): 1.14e-37: 130: 26.58
+	Hs
		980840 TLE3_HUMAN (1-730): 2.82e-146: 447: 57.27		HES6_HUMAN (11-168): 1.14e-37: 130: 26.58
+	Mm
		1143960 TLE1_MOUSE (1-730): 2.22e-148: 453: 59.57		HES6_MOUSE (11-159): 5.3e-35: 123: 28.00
+	Hs
		62468 TLE5_HUMAN (1-197): 8.88e-84: 265: 49.51		HELT_HUMAN (9-172): 5.89e-44: 147: 22.35
+	Hs
		421 TLE5_HUMAN (1-197): 8.88e-84: 265: 49.51		A0A087WSW0_HUMAN (5-172): 1.45e-38: 135: 18.10