HitPredict

Interactor 1: KCNA2 (P16389)
Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2)
Gene: KCNA2

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	12438413, 12435606
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0044224 - juxtaparanode region of axon GO:0045211 - postsynaptic membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 724
+	Mm
		927733 KCNA2_MOUSE (1-499): 1.63e-162: 471: 99.40		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		942333 KCNA1_HUMAN (1-499): 6.18e-145: 426: 77.54		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		558703 KCNA1_MOUSE (1-499): 4e-144: 424: 77.34		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		602901 KCNA3_HUMAN (18-499): 9.83e-138: 411: 74.44		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Hs
		608221 KCNA4_HUMAN (7-499): 4.4e-136: 409: 66.73		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Rn
		548174 KCNA4_RAT (5-499): 4.06e-134: 404: 66.54		DLG4_RAT (1-724): 0: 668: 99.86
+	Mm
		558878 KCNA3_MOUSE (18-499): 1.63e-135: 403: 74.85		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Mm
		1142574 KCNA4_MOUSE (5-499): 3.76e-133: 401: 66.54		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		942389 KCND2_HUMAN (3-498): 2.26e-133: 401: 31.11		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Hs
		608230 KCNA4_HUMAN (7-499): 4.4e-136: 409: 66.73		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		1050021 KCNB2_HUMAN (12-498): 8.4e-130: 400: 31.78		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		608222 KCNA4_HUMAN (7-499): 4.4e-136: 409: 66.73		EM55_HUMAN (2-325): 2.03e-22: 103: 14.41
+	Hs
		602905 KCNA3_HUMAN (18-499): 9.83e-138: 411: 74.44		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Rn
		580271 KCNA5_RAT (2-497): 1.77e-136: 408: 64.72		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Hs
		608224 KCNA4_HUMAN (7-499): 4.4e-136: 409: 66.73		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		608232 KCNA4_HUMAN (7-499): 4.4e-136: 409: 66.73		MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50
+	Hs
		159156 KCNA4_HUMAN (7-499): 4.4e-136: 409: 66.73		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		608231 KCNA4_HUMAN (7-499): 4.4e-136: 409: 66.73		DLG2_HUMAN (225-474): 2.32e-18: 92.1: 21.09
+	Hs
		608244 KCNA4_HUMAN (7-499): 4.4e-136: 409: 66.73		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58
+	Rn
		548175 KCNA4_RAT (5-499): 4.06e-134: 404: 66.54		DLG3_RAT (221-548): 5.99e-15: 80.9: 18.55