HitPredict

Interactor 1: H15 (P16401)
Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)
Gene: H1-5

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.761

Property	Details
Experiments	17671428, 16762841, 16205633, 16191191, 15753125, 15670215, 15607961, 15514162, 15169570, 14701826, 14681231, 14612406, 11980914, 15800615, 11259605
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 226 Hs			1 298
+	Rn
		413197 H1T_RAT (1-219): 2.4e-28: 107: 48.87		Q6P751_RAT (1-298): 2.28e-166: 465: 98.99
+	Hs
		559328 H13_HUMAN (1-184): 1.62e-22: 93.3: 68.48		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Rn
		88903 H11_RAT (1-123): 2.62e-19: 84.4: 65.85		Q6P751_RAT (1-298): 2.28e-166: 465: 98.99
+	Hs
		625377 H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Mm
		794656 H15_MOUSE (39-205): 8.43e-21: 88.7: 92.81		CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26
+	Hs
		414717 H13_HUMAN (1-184): 1.62e-22: 93.3: 68.48		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Dm
		355225 H1_DROME (2-225): 1.13e-26: 104: 32.89		CDK1_DROME (1-289): 1.85e-139: 396: 63.45
+	Rn
		88899 H11_RAT (1-123): 2.62e-19: 84.4: 65.85		CDK1_RAT (1-289): 9.57e-144: 407: 66.21
+	Hs
		414716 H15_HUMAN (1-118): 3.29e-18: 81.7: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		414874 H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Mm
		509472 H11_MOUSE (1-124): 1e-14: 72.1: 67.74		CDK1_MOUSE (1-289): 8.74e-143: 405: 66.21
+	Hs
		559065 H15_HUMAN (1-118): 3.29e-18: 81.7: 100.00		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		559654 H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		489003 H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		960270 H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Mm
		794639 H11_MOUSE (1-124): 1e-14: 72.1: 67.74		CDK5_MOUSE (1-292): 1.87e-138: 394: 59.39
+	Hs
		559352 H13_HUMAN (1-184): 1.62e-22: 93.3: 68.48		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		559612 H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		488949 H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		841171 H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00