HitPredict

Interactor 1: H13 (P16402)
Histone H1.3 (Histone H1c) (Histone H1s-2)
Gene: H1-3

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18850315
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 298
+	Rn
		413197 H1T_RAT (1-219): 3.85e-36: 127: 49.32		Q6P751_RAT (1-298): 2.28e-166: 465: 98.99
+	Rn
		88903 H11_RAT (1-121): 6.42e-22: 91.3: 68.85		Q6P751_RAT (1-298): 2.28e-166: 465: 98.99
+	Hs
		558990 H15_HUMAN (1-116): 3.39e-20: 87.1: 82.20		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		625377 H11_HUMAN (39-182): 9.17e-18: 80.1: 61.81		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Mm
		794656 H15_MOUSE (1-204): 3.87e-22: 92.1: 70.59		CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26
+	Mm
		550489 H12_MOUSE (33-116): 1.07e-16: 77.4: 97.62		CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26
+	Hs
		414717 H13_HUMAN (1-182): 1.29e-30: 114: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Rn
		88899 H11_RAT (1-121): 6.42e-22: 91.3: 68.85		CDK1_RAT (1-289): 9.57e-144: 407: 66.21
+	Hs
		414716 H15_HUMAN (1-116): 3.39e-20: 87.1: 82.20		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		559654 H12_HUMAN (30-174): 6.93e-24: 96.3: 88.28		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		414874 H11_HUMAN (39-182): 9.17e-18: 80.1: 61.81		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		489003 H14_HUMAN (1-116): 3.93e-21: 89.4: 93.10		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Mm
		509461 H12_MOUSE (33-116): 1.07e-16: 77.4: 97.62		CDK1_MOUSE (1-289): 8.74e-143: 405: 66.21
+	Mm
		509472 H11_MOUSE (1-122): 1.46e-16: 77: 69.11		CDK1_MOUSE (1-289): 8.74e-143: 405: 66.21
+	Hs
		559065 H15_HUMAN (1-116): 3.39e-20: 87.1: 82.20		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		960270 H11_HUMAN (39-182): 9.17e-18: 80.1: 61.81		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		559352 H13_HUMAN (1-182): 1.29e-30: 114: 100.00		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		559612 H12_HUMAN (30-174): 6.93e-24: 96.3: 88.28		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		488949 H14_HUMAN (1-116): 3.93e-21: 89.4: 93.10		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		841171 H11_HUMAN (39-182): 9.17e-18: 80.1: 61.81		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00