HitPredict

Interactor 1: H12 (P16403)
Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)
Gene: H1-2

Interactor 2: NSD1 (Q96L73)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)
Gene: NSD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24412544, 30021884
Identification Methods	enzymatic study, proximity labelling technology, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 213 Hs			1 2696
+	Hs
		559470 H13_HUMAN (1-181): 4.78e-25: 99.5: 82.42		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		489205 H14_HUMAN (1-172): 4.96e-18: 80.6: 88.37		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		559217 H15_HUMAN (1-157): 2.05e-15: 74.1: 76.25		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		331717 H12_HUMAN (1-173): 1.53e-22: 92.6: 100.00		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		331706 H14_HUMAN (1-172): 4.96e-18: 80.6: 88.37		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		331716 H15_HUMAN (1-157): 2.05e-15: 74.1: 76.25		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Mm
		990819 H1T_MOUSE (1-196): 2.23e-34: 123: 49.50		EZH2_MOUSE (1883-2067): 5.76e-59: 221: 29.80
+	Hs
		331791 H11_HUMAN (38-182): 2.87e-15: 73.3: 62.07		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		559937 H12_HUMAN (1-173): 1.53e-22: 92.6: 100.00		ZCPW1_HUMAN (166-409): 5.2e-64: 234: 17.63
+	Hs
		489204 H14_HUMAN (1-172): 4.96e-18: 80.6: 88.37		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		559417 H13_HUMAN (1-181): 4.78e-25: 99.5: 82.42		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		559730 H12_HUMAN (1-173): 1.53e-22: 92.6: 100.00		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		971310 H11_HUMAN (38-182): 2.87e-15: 73.3: 62.07		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		971335 H11_HUMAN (38-182): 2.87e-15: 73.3: 62.07		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		559109 H15_HUMAN (1-157): 2.05e-15: 74.1: 76.25		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		971187 H11_HUMAN (38-182): 2.87e-15: 73.3: 62.07		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80