HitPredict

Interactor 1: CTLA4 (P16410)
Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)
Gene: CTLA4

Interactor 2: CD80 (P33681)
T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
Gene: CD80

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.906

The method score is based on:

Property Details
Experiments 11279502, 21982860, 7545666, 20587542
Identification Methods x-ray crystallography, pull down, surface plasmon resonance, protein array
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C2-set_2~V-set, V-set~V-set
Common GO terms GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0009897 - external side of plasma membrane
GO:0042130 - negative regulation of T cell proliferation
GO:0098636 - protein complex involved in cell adhesion
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 223
Hs

1 288
+ Hs
+ Hs
+ Hs
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+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024