HitPredict

Interactor 1: CTLA4 (P16410)
Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)
Gene: CTLA4

Interactor 2: CD86 (P42081)
T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)
Gene: CD86

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	11279501, 21982860
Identification Methods	x-ray crystallography, pull down, protein array
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	V-set~V-set
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0006955 - immune response GO:0009897 - external side of plasma membrane GO:0042130 - negative regulation of T cell proliferation
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 223 Hs			1 329
+	Hs
		560040 CTLA4_HUMAN (1-223): 3.98e-110: 316: 100.00		CD80_HUMAN (2-266): 4.1e-45: 156: 24.00
+	Hs
		560110 CTLA4_HUMAN (1-223): 3.98e-110: 316: 100.00		PD1L1_HUMAN (9-300): 5.98e-41: 146: 15.51
+	Hs
		499346 CD28_HUMAN (30-221): 4.87e-71: 217: 30.69		CD86_HUMAN (1-329): 2.58e-77: 241: 100.00
+	Hs
		560118 CTLA4_HUMAN (1-223): 3.98e-110: 316: 100.00		ROBO1_HUMAN (17-328): 7.45e-23: 101: 11.39
+	Hs
		499345 CD28_HUMAN (30-221): 4.87e-71: 217: 30.69		CD80_HUMAN (2-266): 4.1e-45: 156: 24.00
+	Hs
		255229 ICOS_HUMAN (25-193): 3.59e-63: 196: 17.75		ICOSL_HUMAN (21-228): 2.54e-43: 152: 21.03
+	Mm
		1337441 ICOS_MOUSE (22-193): 1.85e-64: 200: 17.44		ICOSL_MOUSE (20-284): 5.91e-35: 131: 22.91