HitPredict

Interactor 1: BIP (P16474)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein homolog) (GRP-78) (Immunoglobulin heavy chain-binding protein homolog) (BiP)
Gene: KAR2

Interactor 2: SC61A (P32915)
Protein transport protein SEC61 (Sec61 complex subunit SEC61) (Sec61 complex subunit alpha)
Gene: SEC61

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	37968396, 12134063
Identification Methods	affinity chromatography technology, protein complementation assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation GO:0015450 - protein-transporting ATPase activity GO:0031204 - post-translational protein targeting to membrane, translocation GO:0036503 - ERAD pathway
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 682 Sc			1 480
+	Hs
		503812 HSP7C_HUMAN (48-656): 0: 915: 64.27		S61A1_HUMAN (5-465): 0: 679: 56.49
+	Hs
		501910 BIP_HUMAN (44-672): 0: 795: 67.51		S61A1_HUMAN (5-465): 0: 679: 56.49
+	Sc
		560647 BIP_YEAST (1-682): 0: 899: 100.00		SSH1_YEAST (1-465): 3.93e-165: 477: 32.77