HitPredict

Interactor 1: SPTN1 (P16546)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)
Gene: Sptan1

Interactor 2: TNIK (P83510)
Traf2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28671696
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	EF-hand_7~Pkinase
Common GO terms	GO:0030036 - actin cytoskeleton organization GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Mm			1 1323
+	Mm
		82755 B9EKJ1_MOUSE (1-2472): 0: 692: 99.76		TNIK_MOUSE (1-1323): 0: 1277: 100.00
+	Mm
		949304 SPTB2_MOUSE (1-1503): 2.83e-66: 252: 22.55		TNIK_MOUSE (1-1323): 0: 1277: 100.00
+	Mm
		949310 Q68FG2_MOUSE (1-1506): 1.1e-57: 224: 23.68		TNIK_MOUSE (1-1323): 0: 1277: 100.00
+	Hs
		963449 SPTB2_HUMAN (1-1503): 9.12e-67: 254: 22.55		TNIK_HUMAN (1-1323): 0: 1245: 95.15
+	Mm
		949395 DYST_MOUSE (24-2346): 4.45e-36: 154: 10.86		TNIK_MOUSE (1-1323): 0: 1277: 100.00
+	Mm
		949420 MACF1_MOUSE (707-2370): 6.79e-24: 113: 9.72		TNIK_MOUSE (1-1323): 0: 1277: 100.00
+	Hs
		974168 DYST_HUMAN (241-2373): 5.42e-33: 143: 9.50		TNIK_HUMAN (1-1323): 0: 1245: 95.15
+	Mm
		93424 E9Q3P4_MOUSE (1741-2448): 1.39e-14: 82.8: 10.30		TNIK_MOUSE (1-1323): 0: 1277: 100.00
+	Mm
		949273 Q155P7_MOUSE (1741-2448): 1.39e-14: 82.8: 10.30		TNIK_MOUSE (1-1323): 0: 1277: 100.00
+	Hs
		1356411 MACF1_HUMAN (736-2347): 2.04e-11: 72.4: 7.65		TNIK_HUMAN (1-1323): 0: 1245: 95.15
+	Mm
		956963 CE290_MOUSE (400-2442): 2.49e-50: 200: 9.54		M4K4_MOUSE (1-1323): 0: 992: 59.97
+	Hs
		1023039 SPTN1_HUMAN (1-2472): 0: 701: 98.42		STK4_HUMAN (5-470): 3.93e-119: 382: 32.59
+	Hs
		963311 SPTB2_HUMAN (1-1503): 9.12e-67: 254: 22.55		STK3_HUMAN (4-496): 1.39e-117: 377: 30.12
+	Hs
		1313528 CP250_HUMAN (784-2448): 7.52e-50: 198: 10.05		SIK2_HUMAN (15-898): 5.45e-130: 425: 13.75
+	Hs
		513876 DMD_HUMAN (142-2282): 3.62e-39: 164: 11.31		MARK2_HUMAN (8-709): 1.53e-130: 423: 17.94
+	Hs
		159145 DMD_HUMAN (142-2282): 3.62e-39: 164: 11.31		CSKP_HUMAN (22-702): 1.09e-122: 405: 15.80
+	Mm
		251106 DYST_MOUSE (24-2346): 4.45e-36: 154: 10.86		CSKP_MOUSE (22-702): 1.11e-122: 405: 15.80
+	Hs
		974064 DYST_HUMAN (241-2373): 5.42e-33: 143: 9.50		STK3_HUMAN (4-496): 1.39e-117: 377: 30.12
+	Hs
		521610 ACTN1_HUMAN (1862-2210): 4.47e-11: 70.9: 22.25		SIK2_HUMAN (15-898): 5.45e-130: 425: 13.75
+	Hs
		647985 MACF1_HUMAN (736-2347): 2.04e-11: 72.4: 7.65		MARK3_HUMAN (3-717): 6.96e-125: 406: 16.08