HitPredict

Interactor 1: SPTN1 (P16546)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)
Gene: Sptan1

Interactor 2: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	28671696, 28469556
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, Ank_2~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0044877 - protein-containing complex binding GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Mm			1 1730
+	Rn
		555260 SPTN1_RAT (1-2472): 0: 701: 99.64		SHAN3_RAT (1-1730): 0: 618: 98.39
+	Mm
		82760 B9EKJ1_MOUSE (1-2472): 0: 692: 99.76		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		1045505 SPTN1_HUMAN (1-2472): 0: 701: 98.42		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Hs
		862037 SPTN1_HUMAN (1-2472): 0: 701: 98.42		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Mm
		82740 B9EKJ1_MOUSE (1-2472): 0: 692: 99.76		ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58
+	Hs
		1021399 SPTN1_HUMAN (1-2472): 0: 701: 98.42		ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01
+	Mm
		1115941 SPTB2_MOUSE (1-1503): 2.83e-66: 252: 22.55		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		965102 SPTN1_HUMAN (1-2472): 0: 701: 98.42		ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64
+	Hs
		1045573 SPTN1_HUMAN (1-2472): 0: 701: 98.42		SHAN1_HUMAN (491-1637): 5.93e-12: 73.4: 14.37
+	Mm
		561172 SPTN1_MOUSE (1-2472): 0: 699: 100.00		ANK2_MOUSE (134-335): 6.85e-09: 63.5: 31.19
+	Hs
		360612 SPTA1_HUMAN (1-2472): 6.26e-154: 536: 54.81		ANK1_HUMAN (175-669): 2.17e-43: 176: 15.35
+	Hs
		862027 SPTB2_HUMAN (1-1503): 9.12e-67: 254: 22.55		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Mm
		103603 SPTB2_MOUSE (1-1503): 2.83e-66: 252: 22.55		ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58
+	Mm
		103598 Q3UGX2_MOUSE (2-1625): 1.1e-64: 247: 19.54		ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58
+	Hs
		164586 SPTN2_HUMAN (1-1506): 1.78e-58: 227: 23.09		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Hs
		963306 SPTB2_HUMAN (1-1503): 9.12e-67: 254: 22.55		ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01
+	Hs
		556695 SPTB2_HUMAN (1-1503): 9.12e-67: 254: 22.55		ANK1_HUMAN (175-669): 2.17e-43: 176: 15.35
+	Hs
		963292 SPTB2_HUMAN (1-1503): 9.12e-67: 254: 22.55		ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64
+	Hs
		164604 SPTN2_HUMAN (1-1506): 1.78e-58: 227: 23.09		ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64
+	Dr
		1186355 Q7SYE2_DANRE (1980-2470): 1.01e-73: 268: 33.47		MIB1_DANRE (129-324): 1.65e-14: 81.6: 32.50