HitPredict

Interactor 1: FER (P16591)
Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)
Gene: FER

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 457
+	Hs
		426957 FES_HUMAN (1-820): 0: 786: 49.94		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		426954 FES_HUMAN (1-820): 0: 786: 49.94		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		118687 FER_HUMAN (1-822): 0: 934: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		426955 FES_HUMAN (1-820): 0: 786: 49.94		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		846467 BLK_HUMAN (358-817): 1.59e-156: 467: 29.77		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1034994 SRMS_HUMAN (399-819): 3.7e-154: 461: 34.57		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		454829 FGR_HUMAN (363-816): 4.3e-152: 457: 31.29		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		411681 LCK_HUMAN (385-817): 4.77e-152: 456: 30.89		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		118675 YES_HUMAN (319-816): 7.62e-160: 477: 31.45		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118683 SRC_HUMAN (329-816): 4.13e-158: 473: 31.95		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118710 BLK_HUMAN (358-817): 1.59e-156: 467: 29.77		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118671 FYN_HUMAN (335-816): 7.37e-155: 464: 30.60		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		411693 LCK_HUMAN (385-817): 4.77e-152: 456: 30.89		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		118679 FGR_HUMAN (363-816): 4.3e-152: 457: 31.29		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118670 LCK_HUMAN (385-817): 4.77e-152: 456: 30.89		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		411617 LCK_HUMAN (385-817): 4.77e-152: 456: 30.89		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		684476 CSK_HUMAN (450-818): 1.85e-141: 427: 37.53		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62