Interactor 1: TNFA (P16599)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: Tnf

Interactor 2: CASPC (Q920D5)
Caspase-12 (CASP-12) (EC 3.4.22.-)
Gene: Casp12

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.33 0.60 0.445

The method score is based on:

Property Details
Experiments 17623297
Identification Methods pull down
Interaction Type association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002020 - protease binding
GO:0009410 - response to xenobiotic stimulus
GO:0043065 - positive regulation of apoptotic process
GO:0043525 - positive regulation of neuron apoptotic process
GO:0045471 - response to ethanol
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 235
Rn

1 420
+ Rn
+ Rn
+ Hs
+ Rn
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs

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Last updated: 15 Jul 2024