Interactor 1: AT2A2 (P16615)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Gene: ATP2A2

Interactor 2: PPLA (P26678)
Cardiac phospholamban (PLB)
Gene: PLN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.909

The method score is based on:

Property Details
Experiments 31046837, 28890335, 11854448, 12032137, 10809745
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Cation_ATPase_C~Phospholamban
Common GO terms GO:0002026 - regulation of the force of heart contraction
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006874 - intracellular calcium ion homeostasis
GO:0016020 - membrane
and 5 others

more...

Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1042
Hs

1 52
+ Mm
+ Oc
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024