HitPredict

Interactor 1: AT2A2 (P16615)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Gene: ATP2A2

Interactor 2: PAR2 (P55085)
Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
Gene: F2RL1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.582

Property	Details
Experiments	28298427
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1042 Hs			1 397
+	Hs
		561533 AT2A2_HUMAN (1-1042): 0: 1060: 100.00		CCR4_HUMAN (73-392): 3.02e-85: 265: 23.24
+	Hs
		561566 AT2A2_HUMAN (1-1042): 0: 1060: 100.00		GPR17_HUMAN (57-367): 8.1e-79: 249: 29.02
+	Hs
		428908 AT2A2_HUMAN (1-1042): 0: 1060: 100.00		ADRB2_HUMAN (42-383): 5.38e-71: 230: 14.79
+	Hs
		561517 AT2A2_HUMAN (1-1042): 0: 1060: 100.00		OPRD_HUMAN (29-389): 1.77e-70: 227: 20.82
+	Hs
		782452 AT2A3_HUMAN (1-997): 0: 956: 76.85		P2RY2_HUMAN (67-394): 2.77e-79: 250: 26.71
+	Hs
		849697 AT2A3_HUMAN (1-997): 0: 956: 76.85		CCR6_HUMAN (72-394): 3.15e-79: 250: 23.57
+	Hs
		1031036 AT2A3_HUMAN (1-997): 0: 956: 76.85		GPR17_HUMAN (57-367): 8.1e-79: 249: 29.02
+	Hs
		1202701 AT2A3_HUMAN (1-997): 0: 956: 76.85		P2RY8_HUMAN (61-395): 1.57e-77: 245: 34.62
+	Hs
		876172 AT2A3_HUMAN (1-997): 0: 956: 76.85		PAR2_HUMAN (1-374): 1.43e-74: 239: 100.00
+	Hs
		561582 AT2A2_HUMAN (1-1042): 0: 1060: 100.00		P2RY6_HUMAN (76-352): 1.05e-25: 107: 30.07
+	Hs
		530862 AT1A3_HUMAN (4-997): 0: 794: 26.55		CXCR4_HUMAN (73-370): 5.97e-81: 254: 22.62
+	Hs
		530845 AT1A3_HUMAN (4-997): 0: 794: 26.55		P2RY2_HUMAN (67-394): 2.77e-79: 250: 26.71
+	Hs
		530883 AT1A3_HUMAN (4-997): 0: 794: 26.55		GPR17_HUMAN (57-367): 8.1e-79: 249: 29.02
+	Hs
		530923 AT1A3_HUMAN (4-997): 0: 794: 26.55		P2RY8_HUMAN (61-395): 1.57e-77: 245: 34.62
+	Hs
		530861 AT1A3_HUMAN (4-997): 0: 794: 26.55		PAR2_HUMAN (1-374): 1.43e-74: 239: 100.00
+	Hs
		530839 AT1A3_HUMAN (4-997): 0: 794: 26.55		NK3R_HUMAN (32-395): 2.45e-72: 235: 17.60
+	Hs
		392982 AT1A1_HUMAN (3-997): 0: 797: 26.72		ADRB2_HUMAN (42-383): 5.38e-71: 230: 14.79
+	Hs
		530844 AT1A3_HUMAN (4-997): 0: 794: 26.55		OPRX_HUMAN (40-376): 2.58e-68: 222: 23.75
+	Hs
		530835 AT1A3_HUMAN (4-997): 0: 794: 26.55		PTAFR_HUMAN (66-354): 3.98e-34: 131: 29.04
+	Hs
		393214 AT1A1_HUMAN (3-997): 0: 797: 26.72		P2RY6_HUMAN (76-352): 1.05e-25: 107: 30.07