HitPredict

Interactor 1: CL3L1 (P16619)
C-C motif chemokine 3-like 1 (G0/G1 switch regulatory protein 19-2) (LD78-beta(1-70)) (PAT 464.2) (Small-inducible cytokine A3-like 1) (Tonsillar lymphocyte LD78 beta protein) [Cleaved into: LD78-beta(3-70); LD78-beta(5-70)]
Gene: CCL3L1

Interactor 2: CCR1 (P32246)
C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
Gene: CCR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11449371
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006954 - inflammatory response GO:0070098 - chemokine-mediated signaling pathway GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 93 Hs			1 355
+	Hs
		526560 CCL4_HUMAN (1-92): 6.16e-36: 118: 58.70		CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00
+	Hs
		486230 CCL3_HUMAN (1-93): 2.92e-35: 116: 94.62		CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00
+	Hs
		686667 CCL14_HUMAN (1-92): 7.15e-35: 116: 46.24		CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00
+	Mm
		500591 CCL3_MOUSE (1-93): 1.3e-36: 120: 75.27		CCR3_MOUSE (9-355): 1.75e-86: 266: 64.55
+	Hs
		1305163 CCL13_HUMAN (1-93): 4.02e-37: 121: 41.94		ACKR4_HUMAN (8-343): 5.14e-84: 260: 32.16
+	Mm
		500590 CCL3_MOUSE (1-93): 1.3e-36: 120: 75.27		CCR1_MOUSE (1-355): 1.09e-82: 257: 80.00
+	Hs
		561732 CL3L1_HUMAN (1-93): 4.23e-38: 124: 100.00		CCR3_HUMAN (1-355): 4.82e-73: 232: 62.54
+	Hs
		783833 CCL13_HUMAN (1-93): 4.02e-37: 121: 41.94		CCR2_HUMAN (10-326): 3.51e-74: 235: 55.66
+	Hs
		561733 CL3L1_HUMAN (1-93): 4.23e-38: 124: 100.00		CCR5_HUMAN (6-355): 1.7e-72: 230: 54.26
+	Hs
		849619 CCL13_HUMAN (1-93): 4.02e-37: 121: 41.94		CCR3_HUMAN (1-355): 4.82e-73: 232: 62.54
+	Hs
		849654 CCL13_HUMAN (1-93): 4.02e-37: 121: 41.94		CCR5_HUMAN (6-355): 1.7e-72: 230: 54.26
+	Hs
		526564 CCL4_HUMAN (1-92): 6.16e-36: 118: 58.70		CCR3_HUMAN (1-355): 4.82e-73: 232: 62.54
+	Hs
		526565 CCL4_HUMAN (1-92): 6.16e-36: 118: 58.70		CCR5_HUMAN (6-355): 1.7e-72: 230: 54.26
+	Hs
		849616 CCL14_HUMAN (1-92): 7.15e-35: 116: 46.24		CCR3_HUMAN (1-355): 4.82e-73: 232: 62.54
+	Hs
		134400 CCL13_HUMAN (1-93): 4.02e-37: 121: 41.94		ACKR2_HUMAN (4-324): 3.38e-59: 197: 40.30
+	Hs
		134356 CCL4_HUMAN (1-92): 6.16e-36: 118: 58.70		ACKR2_HUMAN (4-324): 3.38e-59: 197: 40.30
+	Hs
		134354 CCL3_HUMAN (1-93): 2.92e-35: 116: 94.62		ACKR2_HUMAN (4-324): 3.38e-59: 197: 40.30
+	Hs
		134380 CCL14_HUMAN (1-92): 7.15e-35: 116: 46.24		ACKR2_HUMAN (4-324): 3.38e-59: 197: 40.30
+	Hs
		830629 CCL13_HUMAN (1-93): 4.02e-37: 121: 41.94		CXCR3_HUMAN (13-318): 1.5e-44: 158: 32.81
+	Hs
		526561 CCL4_HUMAN (1-92): 6.16e-36: 118: 58.70		CXCR5_HUMAN (31-318): 3.49e-44: 157: 32.20