HitPredict

Interactor 1: PLCG2 (P16885)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Gene: PLCG2

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1265 Hs			1 1342
+	Hs
		580925 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		562648 PLCG2_HUMAN (1-1265): 0: 1276: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383591 PLCG2_HUMAN (1-1265): 0: 1276: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337886 PLCG2_HUMAN (1-1265): 0: 1276: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		581010 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383601 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337912 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		562635 PLCG2_HUMAN (1-1265): 0: 1276: 100.00		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		337341 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		434135 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		580937 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		580965 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Mm
		1141452 PLCG2_MOUSE (1-1265): 0: 1276: 94.15		MERTK_MOUSE (659-1033): 2.5e-41: 167: 32.08
+	Hs
		338511 PLCH1_HUMAN (700-1262): 2.32e-103: 363: 21.54		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		580953 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		580983 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		411292 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Rn
		499158 PLCG1_RAT (11-1247): 0: 1145: 49.56		INSR_RAT (329-650): 1.42e-20: 101: 16.71
+	Hs
		537758 PLCD3_HUMAN (577-1187): 2.06e-102: 345: 22.24		INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51