Interactor 1: PLCG2 (P16885)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Gene: PLCG2
Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.56 | 1.00 | 0.754 |
The method score is based on:
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C2~SH2, SH2~SH2, SH2~SH3_1 |
| Common GO terms | GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0043410 - positive regulation of MAPK cascade |
| Homologous interactions | 13 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
