HitPredict

Interactor 1: PLCG2 (P16885)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Gene: PLCG2

Interactor 2: BLK (P51451)
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
Gene: BLK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	8395016
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C2~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1, PK_Tyr_Ser-Thr~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0050853 - B cell receptor signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1265 Hs			1 505
+	Mm
		557351 PLCG2_MOUSE (1-1265): 0: 1276: 94.15		BLK_MOUSE (1-505): 0: 580: 85.74
+	Hs
		411992 PLCG2_HUMAN (1-1265): 0: 1276: 100.00		FYN_HUMAN (1-503): 0: 562: 54.75
+	Mm
		763400 PLCG2_MOUSE (1-1265): 0: 1276: 94.15		FYN_MOUSE (1-503): 0: 561: 54.56
+	Mm
		639456 PLCG2_MOUSE (1-1265): 0: 1276: 94.15		LYN_MOUSE (1-505): 0: 554: 60.16
+	Hs
		433564 PLCG2_HUMAN (1-1265): 0: 1276: 100.00		LYN_HUMAN (1-505): 0: 551: 59.77
+	Mm
		729760 PLCG2_MOUSE (1-1265): 0: 1276: 94.15		BTK_MOUSE (4-498): 1.45e-157: 464: 33.73
+	Hs
		562642 PLCG2_HUMAN (1-1265): 0: 1276: 100.00		BTK_HUMAN (4-498): 2.89e-156: 461: 34.12
+	Hs
		412000 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		FYN_HUMAN (1-503): 0: 562: 54.75
+	Hs
		522758 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		SRC_HUMAN (1-503): 0: 560: 54.22
+	Hs
		580953 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		ABL2_HUMAN (8-503): 2.23e-165: 500: 38.67
+	Hs
		337341 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		ABL1_HUMAN (54-504): 6.77e-163: 492: 41.09
+	Mm
		623690 PLCG1_MOUSE (11-1261): 0: 1148: 49.33		TEC_MOUSE (29-499): 1.49e-162: 476: 37.89
+	Hs
		580990 PLCG1_HUMAN (11-1247): 0: 1149: 49.72		ITK_HUMAN (29-496): 7.21e-159: 466: 36.18
+	Hs
		411745 PLCH1_HUMAN (700-1262): 2.32e-103: 363: 21.54		LCK_HUMAN (1-505): 0: 569: 59.15
+	Hs
		433798 PLCH1_HUMAN (700-1262): 2.32e-103: 363: 21.54		LYN_HUMAN (1-505): 0: 551: 59.77
+	Hs
		434024 PLCB1_HUMAN (837-1241): 1.26e-94: 332: 25.59		LYN_HUMAN (1-505): 0: 551: 59.77
+	Hs
		846042 PLCD1_HUMAN (574-1188): 5.13e-98: 332: 20.53		SRMS_HUMAN (19-498): 7.53e-160: 464: 39.59